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These types of medications are called prodrugs
A qualitative review of case reports found no consistent or biologically plausible pattern of anomalies
United States: Kaiser Family Foundation
Nevertheless, there was some heterogeneity in this observation in the studies with higher baseline age, SBP, use of antihypertensive medications and duration of diabetes (SURPASS-4 and SURPASS-5) where weight loss explained roughly half of the total effect on SBP
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