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L-arginine supplements are generally not recommended for people who have: kidney disease low blood pressure (hypotension) guanidinoacetate methyltransferase deficiency, an inherited condition that impacts arginine metabolism L-arginine may also interact with medications like those used to treat high blood pressure

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These include: Smoking Excessive intake of sugar and refined carbohydrates Exposure to ultraviolet rays Signs of Collagen Deficiency The signs of collagen deficiency are visible to the naked eye