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For patients with clinically low testosterone, hormone optimization through TRT can further improve the ratio of fat lost to muscle preserved

Biochimie 124 , 198206 (2016)

Three changes distinguish it from the native fragment: a lactam bridge between the Asp5 side-chain carboxyl and the Lys10 side-chain amine, inversion to D-phenylalanine at position 7, and norleucine in place of the oxidation-prone methionine at position 4