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The concept of incretin effect was first proposed by Creutzfeldt in the 1970s (1, 2), based on the early observations that insulin secretion was two to three times higher after oral glucose intake than that after an isocaloric intravenous glucose administration (35)

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According to available Phase III data, a head-to-head trial showed non-inferior efficacy and comparable safety

This isn't theoretical laboratory studies confirm eumelanin provides photoprotection while pheomelanin photosensitizes skin cells