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The synthetic accessibility score and MW of 18 were 3.73 and 497.54 g/mol, respectively, which lie between those of ITI-214 and DNS-0056 , indicating a moderate synthesis approach for Compound 18 compared to ITI-214 and DNS-0056 (Daina et al., 2017)

In brief, berberine can reduce anti-apoptotic factors (Bax/bcl-2, caspase), autophagy related proteins (IL-3, Beclin, etc.), A pathology, and activate PI3K-AKT and other signaling pathways, and then produce neuroprotective effect (Figure 1)

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