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The addition of glucagon receptor activation introduces a mechanism not present in either semaglutide or tirzepatide a clinically meaningful increase in energy expenditure driven by enhanced hepatic glucose output and thermogenic signaling

For context on how this titration compares to other GLP-1 peptides, the compound tirzepatide dosing chart shows a similar step-wise approach, and the compounded semaglutide with B12 dosage chart illustrates the same concept for semaglutide

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