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Before starting retatrutide whether in a trial or, in future, as a licensed medicine the following topics should be discussed with your doctor: Your full medical history , including any personal or family history of thyroid cancer, pancreatitis, gallbladder disease, cardiovascular conditions, diabetic retinopathy, or gastrointestinal disorders such as gastroparesis Current medications : Retatrutide may interact with insulin or other antidiabetic agents, potentially increasing the risk of hypoglycaemia

doi: 10.1016/J.ECLINM.2024.102661 49 BettgeKKahleMAbd El AzizMSMeierJJNauckMA

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Clinical and biochemical parameters were assessed at baseline and 6 months, with additional weight assessments at 3 months