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Once inside, those fatty acids are burned as fuel instead of being stored

Melatonin differentially modulates the expression and function of the hMT1 and hMT2 [PMID: 12628486] Laboratory literature summary: Melatonin differentially modulates the expression and function of the hMT1 and hMT2 melatonin receptors upon prolonged withdrawal

That's our job as responsible scientists. It also remains unknown whether there will be any new side effects that pop up if people remain on these drugs for 30, 40, or 50-plus years