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Nanostructured pH-responsive biocompatible chitosan coated copper oxide nanoparticles: a polymeric smart intracellular delivery system for doxorubicin in breast cancer cells
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The BBB achieves this selectivity through the endothelial cells which are connected by tight junctions, supported by the basement membrane, astrocytic end-feet, and pericytes 68
Applied twice daily using 0.5ml per application, this provides 20mg per day of topical peptide (though actual absorption is much lower due to skin penetration limits)
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