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However, even in large real world cohorts of patients with T1D on GLP-1RA, low rates of hypoglycemia were observed ( ADJUNCT ONE and TWO trials, the 2 largest studies with GLP-1RA in T1D, reported increased rates of hypoglycemia
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Cellular thiols, hydroquinones and catecholamines can undergo redox reactions and contribute to intracellular ROS production as well
36,38,39 Compared to oral administration, whereby under 10% actually enters the blood stream, 52 orobuccal administration leads to over 80% absorption directly into the systemic circulation
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