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Activating GLP-1R suppresses exogenous lactate-induced NLRP3 inflammasome activation and histone lactylation in fibroblasts Extracellular acidosis has been reported to directly trigger or augment NLRP3 inflammasome activation [33, 34], and our results showed that the release of lactate was highly enhanced in activated fibroblasts
MIC injections are not FDA-approved for weight loss
7 Semaglutide-treated KO mice similarly failed to suppress RER or elevate circulating long-chain acylcarnitines and were resistant to GLP1R agonist-induced body weight and adipose mass loss (Fig
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