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Researchers investigate Big picture view: In the study, researchers at the University of Virginia specifically investigated small-molecule GLP-1 receptor agonists, such as the Food and Drug Administration (FDA)-approved orforglipron, which can be taken orally and are cheaper to produce than their injectable counterparts

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Taking the supplement between meals, on an empty stomach, is often recommended to prevent competition with other amino acids for absorption, though it can be taken with a small amount of carbohydrates to stimulate an insulin response, which has been shown to enhance the uptake of carnitine into skeletal muscle cells