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These findings have important clinical implications, as approximately 40% of patients with the obesity phenotype of HFpEF have only mild obesity (class I), and the present analyses indicate that these patients benefit just as much as patients with more severe obesity 3

If gastrointestinal symptoms significantly impair quality of life or prevent medication adherence despite conservative management, healthcare providers may consider dose adjustment, alternative agents with potentially different side effect profiles, or referral to a gastroenterologist for specialized evaluation