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From a pharmacological safety perspective, the adverse effect profile of retatrutide based on Phase 1 and Phase 2 clinical trial data (including the NEJM 2023 Phase 2 trial) includes: Gastrointestinal effects: Nausea, vomiting, diarrhoea, and constipation (the most commonly reported side effects in trial participants) Injection site reactions: Redness, swelling, or discomfort at the injection site Cardiovascular effects: Increases in heart rate have been observed in trial participants [21] [22] Hypoglycaemia: Particularly relevant in individuals with diabetes or those taking insulin, sulfonylureas, or other glucose-lowering agents Potential thyroid effects: GLP-1 receptor agonists have been associated with thyroid C-cell changes in rodent studies

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Symptoms If you have an enlarged prostate, you may experience these symptoms: A frequent urge to urinate, especially at night An urgent need to urinate with little warning Difficulty beginning urination Pain or burning during urination Feeling that your bladder never completely empties Dribbling or leaking urine A weak urine stream Intermittentor on/offurine flow Blood in the urine How is an enlarged prostate (BPH) diagnosed

Practical Strategies to Manage Nausea Start Low, Go Slow The single most important strategy is gradual dose escalation