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Glutamine-addicted cells exhibit a decreased survival, or even undergo apoptotic cell death, associated with an increased in DNA damage, an overproduction of ROS or a decreased reduced/oxidized glutathione (GSH/GSSG) ratio
superoxide dismutase), lipid peroxidation marker (e.g
WHO emphasised that the inclusion of these therapies highlights the importance of both non-communicable and infectious disease management at a global scale
OS arises from a disruption in redox homeostasis, where an overproduction of reactive oxygen species (ROS) overwhelms endogenous antioxidant defenses, leading to oxidative damage to lipids, proteins, and DNA (Sies et al., 2024)
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