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The critical distinction: GLP-1 agonists modulate metabolism and hormonal signaling
Patients begin at 0.25 mg once weekly, then increase by 0.25 mg every 28 days until reaching their therapeutic dose or tolerating an optimal level
Furthermore, it lowered Reserpine-induced motor impairment in the rotarod and open-field tests
We use these to establish a robust relationship between GLP-1R trafficking and insulin release in a manner not predicted by the standard pharmacological potency testing for cyclic adenosine monophosphate (cAMP), a primary second messenger coupling GLP-1R activation to insulin secretion 13
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