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J Inherit Metab Dis 45:192202

The safety considerations for Wnt-targeting topical compounds are distinct from those for systemic Wnt pathway modulation, though pre-clinical safety data and the absence of human trial data mean these considerations have not been fully characterised

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7,8 In a three-arm crossover design trial of physically active males with normal blood pressure, participants received a one-time dose of either 8 : Flow mediated dilation of the brachial artery was measured before ingestion of the supplement and one hour after