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As such, TGR5 activation stimulates secretion of GLP-1, while FXR activation reduces GLP-1 secretion, demonstrating a complex interplay between the differential bile acid pool composition and gutbrain signaling 270,271

That leads to a cycle of symptoms going up and down rather than gradually improving over time. Thats why doctors recommend increasing the dosage gradually, which allows your body to get used to the medication while keeping weight loss on track

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Identify Plateaus and Side Effects A 5% weight loss after 12 weeks on a maintenance dose is a good indicator of progress