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Contact your GP or diabetes care team if you experience: Persistent or severe abdominal pain , particularly if localised to the upper abdomen or radiating to the back, which could indicate pancreatitis (a rare but serious adverse effect of GLP-1 receptor agonists) [3] [6] Right upper abdominal pain , with or without fever, jaundice (yellowing of skin/eyes), pale stools or dark urine, which may indicate gallbladder problems Intractable nausea and vomiting preventing adequate oral intake or medication adherence Signs of dehydration , including reduced urine output, dizziness, or dry mucous membranes Unexpected weight loss with poor intake or ongoing vomiting Difficulty swallowing or sensation of food getting stuck, which requires medical assessment Hypoglycaemia symptoms if using Ozempic with sulfonylureas or insulin, especially when food intake is reduced [1] [3] Seek immediate medical attention (call 999 or attend A&E) if you develop: Severe, persistent abdominal pain with or without vomiting, which may indicate acute pancreatitis Symptoms of allergic reaction , such as facial swelling, difficulty breathing, or widespread rash Severe dehydration with confusion, rapid heartbeat, or inability to keep down fluids Persistent vomiting with blood or coffee-ground appearance If pancreatitis is suspected, stop taking semaglutide and seek urgent medical assessment, as advised in the product information
The side effect profiles differ as well
These buzzy drugs are helping people lose weight, plus lower their risk of chronic disease, cancer, and Alzheimers
Given that both of these studies were in patients with OA of the knee (a load-bearing joint), it is likely that a significant proportion of the efficacy observed was due to the significant loss of body weight, reducing pathological joint loading
