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When methylated B vitamins are introduced in high doses or too early, they can abruptly increase methylation activity and lead to mobilization of toxins, increased neurotransmitter turnover, and immune modulation all of which can trigger additional mast cell degranulation in an already sensitized system
Stacking decisions are made between patient and prescribing clinician based on individual response
Some people also think that insulin activity is mediated by inositol
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