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The EVOKE and EVOKE Plus trials are examining oral semaglutide in individuals with early Alzheimer's disease, representing some of the largest prospective studies in this area
it does not establish that any schedule is safe or effective in a living subject, and none of it should be read as a protocol to follow
One study found no significant increase in NAION risk with semaglutide compared to other agents when using broad diagnostic criteria
The principal cell type involved in CNS inflammation is the microglia
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