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Splitting doses (where clinically appropriate) maintains more consistent therapeutic effect and can reduce symptomatic hypotension
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This careful titration is key to optimizing weight loss while keeping side effects manageable
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A large Cochrane review noted that many of the positive studies had methodological limitations, and not all trials found significant benefits. It's also worth knowing that some prominent DHEA researchers have disclosed commercial interests in DHEA supplementation, which is important context when weighing the evidence
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