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Author contributions JS, XG, and YH contributed to the conception and design of the study

In premenopausal women, there is significant interest in whether supra-physiological concentrations of estradiol, as found in combined hormonal contraceptives (CHC), impact womens weight (237)

There is currently no reliable way to predict which patient will respond best to which drug before trying it

Both GCLC protein (Fig 2D) and transcript (Fig EV4A) are low in tumor tissues relative to nontumor tissue, and return to baseline when MYC is turned off in tumors by ad libitum doxy chow feeding (Fig 1A)

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