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Cartilage nodule formation assay in micromass culture Briefly, chondrocytes were seeded in a 12-well plate at a density of 1.010 5 cells per well in a final volume of 10 L and incubated for 2 h at 37 C to allow adherence

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Improvements in these mediators with tirzepatide treatment compared with placebo from SURMOUNT-OSA studies have been previously published and are as follows: ETD between tirzepatide and placebo in study 1 was 16.1% (95% CI 18.0 to 14.2) for body weight, 20.0 events per hour (95% CI 25.8 to 14.2) for AHI and 70.1%min h 1 (95% CI 90.9 to 49.3) for SASHB 13

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