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NNMTs role is to transfer a methyl group to nicotinamide (vitamin B3), creating 1-methylnicotinamide a reaction that consumes cellular methyl donors and depletes nicotinamide adenine dinucleotide (NAD) stores
These pass into the digestive system in the same way as food and are broken down to release the additional vitamin
The Food and Nutrition Board has established recommended dietary allowances and dietary reference intakes for vitamin B12
[1] Without intrinsic factor, dietary B12 cannot be absorbed effectively, leading to deficiency regardless of dietary intake
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