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Rapid weight loss can reduce bone density, which matters more if you are already at risk for osteoporosis, and some muscle is lost along with fat

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Other groups have explored the concept of GLP-1/GIP/glucagon triagonism to obtain extra benefits from adding the benefits of glucagon action (promotion of energy expenditure and amelioration of fatty liver disease) to the twincretin effects of GLP-1 and GIP

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