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doi: 10.1186/s12888-016-1049-5 20 CarlsenSMMartinussenMPVankyE
The mechanisms underlying IGF-1 LR3's anabolic effects involve activation of the PI3K/Akt/mTOR signaling pathway, which stimulates ribosomal protein S6 and translation initiation factors downstream of mTORC1, thereby enhancing protein synthesis
Synthetic biology-based approaches, such as SYNB1891, a live microbial vector delivering STING agonists, have been evaluated for intratumoral immune activation in metastatic tumors (NCT04167137)
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