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Similarly, and consistent with a previous report of comparable GSTP1 expression in A2780 cells and the cisplatin-resistant derivatives C70 and C200 (Townsend et al, 2002), we did not detect a significant increase in GSTP1 expression in platinum-resistant A2780DPP cells

All animals were treated humanely, and all studies were carried out in accordance with good laboratory practice (GLP) (China Food and Drug Administration, CFDA) guidelines for nonclinical laboratory studies of drugs issued by the National Scientific and Technological Committee of the Peoples Republic of China

In addition, environmental pollution is an important factor leading to zinc excess in animals