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Conclusions Despite the medical complexity and the later disease stage, patients with T2DM in this study experienced significant reductions in HbA1c within 6 months following initiation of oral semaglutide
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Goodman et al
levothyroxine does not inhibit or induce CYP3A4 Cardiovascular overlap / both drugs affect heart rate and blood pressure via different paths Hyperthyroid state risk / excess levothyroxine increases heart rate and may counteract amlodipine antihypertensive effect Hypothyroid state risk / under-replaced thyroid raises LDL, diastolic BP, and cardiovascular load FDA levothyroxine label instruction / separate from all other oral medications by at least 30-60 minutes Key monitoring labs / TSH, free T4, resting heart rate, seated blood pressure Do Amlodipine and Levothyroxine Directly Interact at the Molecular Level
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