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What is the primary mechanism of action for 5-Amino-1MQ
While effective, this approach carries risks including supraphysiological hormone levels, suppression of natural GH production, and side effects such as fluid retention, joint pain, carpal tunnel syndrome, and potential insulin resistance
Assessing futility (non-response) In the ESSENCE trial, 37.1% of participants treated with semaglutide did not resolve MASH, and 63.2% did not have a reduction in fibrosis without worsening of steatohepatitis by week 72
There is also substantial impact on overall lifespan with an estimated 520 years of life lost for individuals with a BMI 45 [9]
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