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Pigmentation can occur in the absence of UV exposure, though existing evidence suggests UV exposure amplifies the melanogenic response [12]
Small molecule ago-allosteric modulators of the human glucagon-like peptide-1 (hGLP-1) receptor
The adverse reactions that occurred in at least two (6.1%) REPATHA-treated patients, and more frequently than in placebo-treated patients, included: Upper respiratory tract infection (9.1% versus 6.3%) Influenza (9.1% versus 0%) Gastroenteritis (6.1% versus 0%) Nasopharyngitis (6.1% versus 0%) In a multicenter, open-label 5-year extension study, 106 patients with HoFH, including 14 pediatric patients, received 420 mg of REPATHA subcutaneously once monthly or every 2 weeks [see Clinical Studies (14)]
53 Moreover, there was a linear relationship between HRQoL and BMI
