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Huang J, et al

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Abbreviations 4-HNE: 4-Hydroxynonenal ACE2: Angiotensin-converting enzyme 2 Ang 17: Angiotensin 17 Ang I: Angiotensin I Ang II: Angiotensin II COVID-19: Coronavirus disease 2019 CoVs: Coronaviruses GSH: Glutathione (reduced form) GSSG: Glutathione (oxidized form) HIV: Human immunodeficiency virus MERS-CoV: Middle East respiratory syndrome coronavirus NAC: N-acetylcysteine NADP + : Nicotinamide dinucleotide phosphate (oxidized form) NADPH: Nicotinamide dinucleotide phosphate (reduced form) PDI: Protein disulfide isomerase RAAS: Reninangiotensinaldosterone system RBD: Receptor-binding domain RBM: Receptor-binding motif RONS: Reactive oxygen/nitrogen species S protein: Spike protein SARS-CoV-2: Severe acute respiratory syndrome coronavirus 2 TF: Transcription factor TRX: Thioredoxin TRXR: Thioredoxin reductase VD: Vitamin D References Li F (2016) Structure, function, and evolution of coronavirus spike proteins

Hyperpigmentation Concerns Skin hyperpigmentation is generally triggered or exacerbated by diverse factors including hormonal changes, nutritional status, but the major actor is sun exposure [17, 19]