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Clinical applications of molecular biomarkers in prostate cancer detection

If the local pH environment is unsuitable, the peptide may show cloudiness, floating particles, clumping, gel-like behaviour, aggregation, or precipitation

People typically lost at least 20% of their body weight after a year of treatment

Intrinsic sympathomimetic activity (ISA) Partial agonists Example: Pindolol Mechanism of Action 1 blockade: Heart rate Myocardial contractility Cardiac output BP 2 blockade: Bronchoconstriction Peripheral vasoconstriction Renin release from kidneys RAAS activation Clinical Indications Hypertension Ischemic heart disease / angina Post-myocardial infarction Heart failure (HFrEF carvedilol, metoprolol, bisoprolol) Arrhythmias (AF, SVT, VT) Migraine prophylaxis Hyperthyroidism / thyrotoxicosis Anxiety / stage fright (propranolol) Adverse Effects Bradycardia Hypotension Fatigue Cold extremities Worsening asthma/COPD (non-selective) Sexual dysfunction Masking of hypoglycemia symptoms (diabetics) Contraindications Severe bradycardia Heart block (2nd or 3rd degree) Decompensated heart failure Severe asthma / COPD (for non-selective) Cardiogenic shock Drug Interactions Other antihypertensives additive hypotension Antiarrhythmics bradycardia Insulin / oral hypoglycemics masked hypoglycemia 1-selective preferred in asthmatics and diabetics Abrupt withdrawal rebound angina or MI Carvedilol is used in heart failure for mortality benefit Monitor HR, BP, renal function, and blood glucose in diabetics To view or add a comment, sign in More Relevant Posts Beta-blockers are drugs that block -adrenergic receptors, reducing the effects of adrenaline and noradrenaline on the heart and other organs