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What I'm confident about: Triple agonists represent a major advancement in metabolic medicine Retatrutide's Phase 2 results are genuinely impressive This medication could help people who haven't succeeded with other treatments The liver benefits are particularly exciting for people with fatty liver disease What I'm watching closely: Long-term safety data from Phase 3 trials Real-world muscle loss and how to prevent it Cost and insurance coverage Who experiences the best results vs

We identified key regions in the p53 transactivation domain (TAD) involved in FOXO4 binding and designed an optimized peptide inhibitor (CPP-CAND) with improved cell permeability

The use of two complementary peptides enables more complex experimental design compared to single-compound studies