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However, in A Diabetes Outcome Progression Trial (ADOPT), metformin exhibited a reduced risk of monotherapy failure compared with the sulfonylurea glibenclamide (known as glyburide in the USA and Canada) and slower rate of loss of beta cell function, although it was inferior to the thiazolidinedione rosiglitazone [20]

Moreover, Valentino et al

Rapid weight loss can also cause hair thinning, skin dryness and dullness, and brittle nails due to nutrient shifts

Over time, you may get mild to moderate inflammation (when MASLD becomes MASH), scarring (fibrosis), and severe liver damage that doesnt heal (cirrhosis).

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