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Those experiencing gastrointestinal side effects may benefit from oral rehydration solutions or electrolyte-containing beverages

In Phase 2, participants were randomized to multiple doses, such as: 1 mg fixed dose 4 mg, starting at 2 mg or 4 mg 8 mg, starting at 2 mg or 4 mg 12 mg, starting at 2 mg All doses were administered subcutaneously once weekly, and dose escalation was intended to improve tolerability

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The SURMOUNT-4 trial showed that when tirzepatide was continued, people maintained and even augmented weight loss, but when it was withdrawn, significant regain followed