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By promoting healthy methylation and converting homocysteine into methionine, TMG helps maintain already-healthy homocysteine levels to support cardiovascular and neurological health

In contrast to common obesity, where cardiovascular risk reduction drives intervention, the main rationale for treatment in MC4R -deficient patients shifts toward alleviating mechanical complications (e.g., sleep apnea, osteoarthritis), preventing diabetes (hyperinsulinemia is common despite relative euglycemia), and improving quality of life [30]

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