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Biochemical Society Transactions
the original rodent study used 5 mg/kg, which when scaled allometrically to human equivalents suggests doses in the 5-10 mg range for a 70 kg adult, though allometric scaling from mice to humans is an imprecise science
The 60 to 90 second hold time maximizes the amount of medication that absorbs through the sublingual tissue before saliva dilutes it
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