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The medication is metabolised in the liver and excreted primarily through the kidneys
Within the kidneys the osmotic diuretics act primarily at the level of the proximal tubule and the descending limb of the loop of Henle
When the receptor for either molecule was removed from the mice, the drug was less effective
This kind of explicit, upfront gating and the willingness to say we cant serve you, heres free content instead is more transparent than the industry norm of capturing a lead and figuring it out later
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