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A clinical trial on semaglutide shows that patients taking higher doses of semaglutide (1.7 mg and 2.4 mg once weekly) showed an average weight loss of 6.9% after 3 months
[1][2] Why CVS Caremark Dropped Zepbound Better pricing from Novo Nordisk: CVS Caremark negotiated preferred pricing for Wegovy (Novo Nordisk's GLP-1), making it their preferred option Cost control: GLP-1 medications are expensive (~$1,086/month for Zepbound), and PBMs manage costs by limiting options Exclusivity agreements: Drug manufacturers compete for preferred formulary status by offering rebates What This Means for Aetna Members Standard Aetna plans: Zepbound excluded for weight loss (Wegovy preferred) Self-funded employer plans: Can choose to keep Zepbound covered Covered alternatives: Wegovy, Saxenda, Qsymia remain on most Aetna formularies For more details on how CVS Caremark affects GLP-1 coverage across all insurers: Complete CVS Caremark Guide Now that you understand the CVS Caremark connection, your plan type determines whether you can override it
Zepbound, however, offers a combination of active ingredients aimed at providing similar benefits, but with a potentially different mechanism of action or added effects
Toxicol Appl Pharmacol 1992;114(1):88-96
