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Though research is ongoing, studies suggest that gradually reducing the dose instead of suddenly stopping may lower the risk of weight regain
Research from the STEP 1 exploratory analysis using DEXA scans revealed that semaglutide-induced weight loss comprises approximately 60 percent fat mass and 40 percent lean mass
A separate 2025 literature and patent review published in Pharmaceuticals (Jzwiak et al.) reached a similar conclusion
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