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A recent multicentre placebo-controlled trial of liraglutide efficacy in adolescents and children with PWS without diabetes showed that although adolescents treated with liraglutide 3 mg had lower hyperphagia scores at week 52, changes in BMI standard deviation score from baseline to week 16 and week 52 did not significantly differ (38)

A volcano plot was drawn with -log (p -adjust ) as the abscissa and logROR as the ordinate

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(2.2, 2.3) SYNJARDY XR: take orally once daily with a meal in the morning, with gradual dosage escalation to reduce the gastrointestinal adverse reactions due to metformin HCl