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Cigarette smoke also contributes to mitochondrial DNA mutations, which increases ROS production and exacerbates neutrophilic airway inflammation (128)

There is a lack of long-term data beyond 23 months, and large-scale, randomized controlled trials are limited, according to Anetta Reszko, MD, a board-certified dermatologist and dermatologic surgeon, a clinical assistant professor of dermatology at Weill Cornell Medical College