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Agents in this group include peroxisome proliferator-activated receptor agonists (e.g., pioglitazone, elafibranor, saroglitazar), bile acid-farnesoid X receptor axis regulators (obeticholic acid), de novo lipogenesis inhibitors (aramchol, NDI-010976), and fibroblast growth factor 21/19 analogs
Drugs That Make GLP-1 Muscle Cramps Worse Several medication classes frequently co-prescribed with GLP-1 agonists amplify cramp risk through additive electrolyte depletion or direct myotoxicity
Many patients wonder whether these medications can be safely combined
Some studies suggest GLP-1s may even have neutral or protective effects on bone health
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