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Among the most notable are MSDC-0160 (PNU-91325) and MSDC-0602K, which show potent insulin-sensitizing effects in preclinical 52,53,54 and clinical 53,55 studies despite exhibiting much reduced ability to bind and signal via PPAR 51
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These should definetely be approved for T1s The resistance to using GLP-1 RAs in type 1 diabetes can no longer be justified as a simple lack of indication. Studies such as Viral Shah et al
Haworth WN, Hirst EL: Synthesis of ascorbic acid
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