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Increased intestinal permeability and blood-brain barrier disruption may allow inflammatory signaling to influence the central nervous system
In fact, Wegovy may have less of an impact on depression than other medications: A recent study funded by the National Institutes of Health found that people using semaglutide had a 49-73% lower risk of suicidal ideation compared to taking other obesity or type 2 diabetes medications
Ma S, Huang Q, Tominaga T, Liu C, Suzuki K
Triglyceride levels decreased dose-dependently, with high-dose treatment producing 30-40% reductions
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