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doi: 10.3389/fendo.2019.00260 2 LingJChengPGeLZhangD-HShiA-CTianJ-Het al

Because MC1R selectivity means little of the appetite/libido effect seen with MT-II, more frequent dosing is typically used for tanning

In the SURMOUNT-2 trial, which enrolled participants with type 2 diabetes, weight loss was somewhat lower but still substantial

Alternative pharmacological options with established safety profiles include: Semaglutide (Wegovy): Another GLP-1 receptor agonist with robust weight loss data and cardiovascular risk factor improvements (with cardiovascular outcome benefits demonstrated in the SELECT trial) Liraglutide (Saxenda): Daily GLP-1 agonist injection licensed for weight management Orlistat: Lipase inhibitor that reduces dietary fat absorption, available over-the-counter or on prescription Each has distinct side effect profiles and may suit different patient populations