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Isoleucine, leucine, and valine (branched-chain amino acids) Oxidation of isoleucine, leucine, and valine, collectively described as branched-chain amino acids, occurs in all tissues and is a key fuel source for skeletal muscle
Mitophagy constitutes a critical adaptive survival mechanism for tumor cells under therapeutic pressure by eliminating treatment-induced damaged mitochondria, limiting reactive oxygen species accumulation, and maintaining mitochondrial homeostasis, thereby providing a buffering capacity for the development of resistance
They also recommend them as a possible initial treatment in those with diabetes and certain comorbidities such as obesity, chronic kidney disease and prior significant cardiovascular events
