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Insulin gene transcription and translation, as well as the enhancement of glucose-stimulated insulin secretion (insulinotropic effects), are caused by GLP- 1 receptor activation in the beta cell
I've always been able to manage to lose weight (verrry slowly) through a combo of diet and exercise, but because I've had to be on pretty restrictive diets (think extremely low-carb and extremely low-cal) to get the weight off, they were hard to maintain, and it would always come back no matter how much I'd lost
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