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It is manufactured by solid-phase synthesis, typically as a research chemical
It has been studied specifically for its role in intestinal inflammation, with preclinical research showing it can reduce pro-inflammatory cytokine activity in gut tissue
Thus, dietary supplement B 12 supplementation at 500 to 1000 g per day allows pernicious anemia and certain other defects in B 12 absorption to be treated with daily oral megadoses of B 12 without any correction of the underlying absorption defects
Peptide signaling research may also intersect with mitochondrial-derived peptide pathways in broader cellular studies
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